MoBiDiK PRO - Modular Bioproduction Disposable and Continuous

Project objectives

Strong growth potential but at the same time reduced annual amounts per API increase the cost pressure in the pharmaceutical industry. Continuous processing for the production of monoclonal antibodies (mAb) is a promising alternative to conventional batch processes. During the first MoBiDiK project (2011-2014) a fully continuous mAb process in miniplant scale was realized. All process steps were realized with single-use equipment. Yield and product quality achieved were comparable to existing batch processes.   

Based on these results, a GMP-compliant process will be developed within the MoBiDiK PRO project. Instead of a fully continuous mAb process, a hybrid process consisting of a fed-batch upstream and a continuous downstream will be realized. Through the application of single-use equipment and closed processing the facility footprint and therefore the resulting investment costs are minimized.    

     

 

Conventional production process for monoclonal antibodies (source: Kauling, 2009)

INVITE's contribution

The INVITE Team contributes the development of production concepts and their physical demonstration in a pilot plant. By using innovative simulation and optimization methods, INVITE develops the optimal cascade and design of different unit operations to build an optimized production process. INVITE is the link between the different sub-projects from the up- and downstream parts and for this reason INVITE plays a key role within this project.

Project partner

Contact

Dr. Martin Lobedann, Dr. Sven-Oliver Borchert, M. sc. Laura Holtmann

Project duration

3 years up to 31.07.2017

Trade fairs & Events

30th May - 1st June 2017 in Dubrovnik, Croatia

Virus & TSE Safety Forum more

25.01.2017 in Frankfurt, Germany

Open Workshop - Tackling the future of plant operation more

Press & News

05/03/2017 INVITE Kolloquium with Prof. Dr. Jörg Breitkreutz and Dr. Julian Quodbach more
07/26/2016 INVITE Colloquium with Prof. Dr. Dr. h.c. Peter Kleinebudde more

Map Directions

INVITE GmbH
Chempark Leverkusen
Building W32
51373 Leverkusen
Germany

Tel.: +49 214 31203-0
Email